Best Picks for Week 4 of the 2025 College Football Season

College Football Odds Report for Week 4

Before diving into picks, let’s scan the current college football odds and how they’ve moved. Oddsmakers opened several marquee matchups with tight lines, reflecting how balanced the field looks early this season. Line movement shows where bettors are leaning, and monitoring changes helps identify value.

For example, a game like Texas vs. Oklahoma State opened with Texas favored by 6.5. Early sharp money pushed the line to -7.5. This means if you liked Texas, you wanted to grab the number earlier, while late bettors may find more value backing Oklahoma State to cover. This type of shift highlights how college football lines evolve during the week and why tracking movement is part of smart college football betting.

Best Moneyline Pick for College Football Week 4

North Carolina (+140) vs. Miami

Taking North Carolina as a moneyline underdog makes sense for Week 4. Miami has the talent edge in the trenches, but North Carolina’s passing attack has been consistent through three weeks, averaging 315 yards per game. Quarterback play often decides close college football scores, and UNC’s veteran signal-caller has proven reliable in high-leverage spots.

Miami’s secondary has shown cracks, allowing opponents to complete over 65 percent of passes. Add in that North Carolina has won three of the last five meetings, and the +140 number is worth grabbing. It’s an example of how point spread betting can be set aside when the underdog has a real shot to win outright.

When using online sports betting websites, look for spots where an underdog has both momentum and matchup advantages. This one fits that mold, and it’s a great way to find value outside the favorites.

Best Spread Pick for College Football Week 4

USC (-6.5) vs. Arizona State

USC enters Week 4 as a touchdown favorite, and the spread feels like a value before it climbs. The Trojans’ offense ranks top five in total yards per game, and their passing attack is averaging over 34 points per contest. Arizona State has struggled defensively, allowing opponents to hit the over under in two straight games.

Point spread betting trends show USC covering in four of their last five Pac-12 games. Their fast pace makes it difficult for opponents to keep up, and Arizona State’s inconsistent quarterback play adds risk for the home team. With USC sitting under a full touchdown, the -6.5 spread offers an edge.

This type of play is a good example for those learning online sports betting how to spot value. Catching numbers before they cross key thresholds like 7 or 10 can make or break a bet.

Best Totals Pick for College Football Week 4

Florida State at Clemson – Over 55.5

This rivalry always delivers, and 2025 looks no different. Florida State brings an explosive offense averaging 38 points per game, while Clemson’s defense has looked shaky, giving up big plays in back-to-back weeks.

The over under of 55.5 might look high, but context matters. In their last four meetings, the teams have combined for 61 points per game. Florida State’s passing attack has opened up the field, while Clemson still carries enough firepower to keep pace. Weather looks clear, so there are no excuses for low scoring.

Bettors using online sports betting apps should keep an eye on live movement. If the game starts fast and defenses look tired, college football live totals can climb quickly. Locking in the over early offers the best shot at value.

Safer Parlay Picks for College Football Week 4

Parlay: USC -6.5, Michigan -10.5, North Carolina +3.5

This safer three-leg parlay combines strong favorites with a manageable underdog spread. USC’s high-tempo offense makes them reliable to cover. Michigan, favored by double digits, faces a weaker non-conference opponent and should control from start to finish. North Carolina at +3.5 provides cushion even if they fall short of the outright upset.

This example shows how parlay bets can balance risk. By mixing spreads and underdog covers, bettors increase their chance of cashing while still chasing a solid payout. For many fans using online sports betting USA platforms, this type of ticket is a go-to weekend play.

Riskier Parlay Picks for College Football Week 4

Parlay: North Carolina Moneyline, Clemson Moneyline, Arizona State Moneyline

For those chasing a higher payout, this riskier three-leg parlay offers bold options. Backing North Carolina outright against Miami already brings plus money. Adding Clemson to bounce back at home against Florida State gives this parlay extra edge. Arizona State, though inconsistent, could surprise USC if turnovers flip the game.

Riskier parlays like this one show why bettors love the thrill. While unlikely all three hit, the payout is significant. When using online sports betting online platforms, these bets are common ways for fans to test long-shot angles. It’s a reminder to keep bankroll discipline but still leave room for high-reward tickets.

Watching College Football on TV and Tracking Scores

Betting is always more fun when you can watch the action unfold. College football on TV in Week 4 features several nationally televised games, including Florida State vs. Clemson and USC vs. Arizona State.

Tracking college football scores live allows bettors to follow their picks in real time. For example, many online sports betting apps now integrate scoreboards and live betting options, letting you adjust your card as the game unfolds. If USC starts slow, a live spread might offer better value than pre-game numbers.

Following along live also sharpens your understanding of how lines move and how to spot value quickly.

Final Takeaways for College Football Week 4

College football betting in Week 4 offers something for everyone: underdog moneylines, favorites covering spreads, and totals shaped by high-tempo offenses. The key is spotting where college football betting odds misalign with performance trends. Whether you prefer safer plays or riskier parlays, always keep bankroll discipline in mind.

Online sports betting legal options in the USA continue to expand, making it easier to jump in. The real edge comes from preparation and timing — knowing when to grab lines before they move.

Check out our full betting toolset to start spotting profitable lines.