2025/2026 Arizona Cardinals Schedule for Sports Betting

Week 1: Cardinals vs. 49ers – The Measuring Stick

The Cardinals open their season against division rival San Francisco. Arizona’s been an underdog in most nfl odds in vegas projections, and this one’s no different. The 49ers come in as 7-point favorites.

Bet to Watch: If the NFL injury report favors the Cards, take the spread. If not, live-bet the under. These matchups tend to get grindy fast.

Week 3: Cardinals at Packers – Freeze or Fire?

Early-season games at Lambeau can go sideways fast, especially for dome teams. If you’re into online sports betting, keep an eye on the weather. Cold air + young QB = disaster.

Bet to Ignore: Props on deep passing yards. Arizona might not get the ball past midfield.

Week 5: Cardinals vs. Jets – Underdog Moneyline Alert

Zach Wilson? Kyler Murray? This could get chaotic. The Jets D is nasty, but Arizona at home as a +3 underdog smells like value.

Bet to Watch: Cardinals moneyline if Kyler’s healthy and the NFL injury report looks clean.

Week 7: Cardinals vs. Rams – Trap Game?

This feels like a classic “everyone bets the Rams” spot. But Arizona beat them last year with less talent. That’s why you don’t follow the nfl betting public.

Shurzy Pick: Cardinals +3.5 if the line holds. If it drops, walk away.

Week 9: Cardinals at Seahawks – Loud, But Winnable

Seattle’s always a tough trip. But Kyler's scrambling could mess up Seattle’s zone coverage. Check the nfl betting props for rushing yards—Kyler could break 50 on the ground.

This is the kind of game where same-game parlays can hit big if you play smart.

Week 10: Cardinals vs. Patriots – Defense Optional

If you like points, this might not be your week. Both teams struggled on offense in 2024, and this year doesn’t look much better. Hammer the under.

Bet to Avoid: Touchdown scorer props. These teams couldn’t finish a drive with GPS.

Week 12: Cardinals at Cowboys – Let’s Get Weird

Dallas is dominant at home, but this could be the week to zig when everyone zags. Think: Dak throws two picks, Arizona gets a defensive TD, and all your friends look dumb for loading up on the Boys.

Shurzy Vibe: Bet the Cardinals spread and sprinkle the moneyline. Could be a monster payday.

Week 13: Cardinals vs. Bears – Must-Win, Must-Bet

Playoff hopes? Maybe. Either way, this is a must-win for both teams. That’s where online sports betting websites make their money—people bet emotionally. You don’t. You bet with receipts.

Prop to Watch: Kyler Murray anytime touchdown.

Week 15: Cardinals at Eagles – Fade or Pray?

Philly's a buzzsaw, and this could be a blowout. This might be your best “bet against your own team” moment of the year.

Best NFL picks this week: Eagles -6.5 if the line stays under a touchdown.

Week 17: Cardinals vs. Lions – Shootout Potential

This one could be fireworks. The Lions love to throw, and Arizona’s corners are… let’s say generous. Expect nfl betting spreads to be tight, and totals to be high.

Smart Play: Bet the over early before it climbs. Look at nfl betting props on WR receiving yards.

Week 18: Cardinals vs. Seahawks – Everything on the Line?

This might be a playoff play-in. Or maybe not. Either way, it’s one of the most bettable matchups on the arizona cardinals schedule.

Best Bet: If Seattle needs this win and Arizona’s eliminated, bet Seahawks 1st half spread. Motivation matters.

Honorable Mentions: Other Games to Watch

• Week 4 vs. Commanders – Potential blowout win. Bet big if the line is under -4.
  
  
• Week 6 at Falcons – Let the public overreact. Watch for a bounce-back spot if Arizona loses Week 5.
  
  
• Week 11 bye – Your bankroll gets a breather. Reset, review, and re-up for the final stretch.

Final Betting Tips for the 2025 Cardinals

1. Watch the injury reports. Especially for Kyler. One tweak and the entire line shifts.
   
   
2. Fade the hype. If everyone loves Arizona one week, it's probably a trap.
   
   
3. Use Shurzy tools. They’re faster than your buddy and don’t need spreadsheets.
   
   

Remember, the Arizona cardinals schedule isn’t just for watching. It’s for winning. If you know what to look for, there’s value everywhere—spreads, props, totals, even live lines.

So bet smart. Brag loud. And don’t forget:

Check out our full betting toolset to start spotting profitable lines.