Best Picks for Week 1 of the 2025-26 NFL Season

Taking the Eagles at -7 feels straightforward: they’re defending champs, and Dallas often stumbles out of the gate. Bookmakers quickly adjusted the spread from -6 to -7, but there’s still value here given Philly's incredible track record—they've covered the spread in 14 of their last 15 home openers.

Dallas faces significant changes this offseason, especially along their offensive line following the retirement of veteran Zack Martin. Add uncertainty with their QB and running backs' health, and it’s clear Dallas might be starting slow.

Philly, on the other hand, consistently dominates at home, outscoring opponents by an average of over eight points in their last ten home games. Grab this Eagles -7 pick early—it’s likely to climb as game day approaches. 

Expect fireworks in this Week 1 showdown between the Bills and Ravens. Sportsbooks anticipate plenty of scoring, setting the total at a high 51.5 points.

Both teams ranked at the top offensively last season, with the Bills leading the AFC with 30.9 points per game and the Ravens close behind at 30.5. Dynamic offenses and questionable secondaries set the stage for a high-scoring game.

Weather conditions in Orchard Park are typically mild around Labor Day, minimizing any disruption to the passing game. Betting the over feels smart here, especially with the explosive potential on both sides. 

Safer Parlay: Eagles -7, Commanders -7, Lions +1.5

This trio combines reliable favorites with a solid underdog. With Dallas’ offensive reshuffling, the Eagles -7 feels solid. The Commanders at -7 also look good against a Giants team still figuring things out on the O-Line. Adding Detroit +1.5 rounds this parlay nicely, especially since the Lions covered 12 of 18 games last season. At around +600 odds, it offers a great mix of safety and potential payoff.

Riskier Parlay: Lions Moneyline, Ravens Moneyline, Giants Moneyline

Feeling bold? Pairing the Lions' solid chance against Green Bay, the Ravens in a tight game with Buffalo, and the Giants' potential upset offers high risk but huge rewards at roughly +1200 odds. While definitely riskier, this pick offers genuine potential with the Ravens and Giants well-positioned for early-season surprises.

Our picks for Week 1 of the 2025 NFL season are leaning on trends and early market tells. Spreads at or under -7 on dominant home teams, plus money spots tied up with defensive advantages, and high totals shaped by even higher tempos to give you a clear roadmap, use these insights to build a diverse card, and remember to keep good bankroll discipline.