Best Picks for Week 1 of the 2025-26 NFL Season
The 2025-26 NFL season is almost here, and it’s kicking off with some great Week 1 matchups, including the reigning Super Bowl champs, the Philadelphia Eagles, facing the Dallas Cowboys on September 4th. Bettors are already diving into early lines, hoping to beat the books before odds start moving. Let’s break down some standout picks based on early numbers.
Picking Detroit here might seem a little bold, but hear me out. Sportsbooks started with the Packers favored slightly at 1.5 points, but now are just down to 1 point favourites. Detroit sits at a tempting +108, giving about a 48% win probability.
Last season, the Lions dominated with a 15-2 overall record, including an undefeated run in the NFC North, clearly signaling momentum on their side. Detroit brings back their entire starting O-Line, providing critical depth and stability.
Though the Packers ranked 7th in rushing yards allowed last season (4.0 yards per attempt), the Lions weren’t far behind, allowing slightly more yards per rush. These two teams are evenly matched offensively, both averaging about 4.7 yards per rushing attempt last season.
Historically, Detroit’s won six out of their last ten games against Green Bay, making this plus-money Lions pick hard to pass up.
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