Best Picks for Week 2 of the 2025-26 NFL Season

Best Moneyline Pick: Jacksonville Jaguars (+114) vs. Cleveland Browns

This is one of our favorite underdog plays for NFL betting today. The Jaguars come into this matchup with a rested Trevor Lawrence and a defense that just held the Titans to 13 points. They’re a live dog this week at +114, giving them an implied win rate of about 46%.

Cleveland struggled in Week 1, especially on third downs, converting only 3 of 12 attempts. With Jacksonville’s pass rush looking sharp and Lawrence distributing the ball to four different receivers, we like this moneyline value. Jacksonville has also won three of their last four against the Browns.

Point spread betting favors Cleveland slightly, but at these odds, the Jaguars offer solid upside. If you're wondering where to bet on football games with competitive underdog lines, this matchup is a smart place to start.

Read more: Looking for the ultimate guide to NFL betting this season? We've got you covered right here!

Best Spread Pick: Detroit Lions (+2.5) vs. Los Angeles Rams

This game features two high-powered offenses, but Detroit gets the edge with their defense. They covered the spread in 12 of 18 games last season and held the Packers under 20 points in Week 1. Getting +2.5 against a Rams squad that’s still adjusting on defense feels like strong value.

Detroit’s offensive line remains one of the best in football, giving Jared Goff time to find his rhythm. The Rams, on the other hand, allowed 5.3 yards per play in Week 1 and couldn’t slow down deep passing routes.

This is one of the sharper NFL picks Week 2 spread bettors are leaning on. Expect this line to shrink by game day as smart money comes in.

Best Totals Pick: Miami Dolphins at Buffalo Bills – Over 50.5

This is shaping up to be a high-scoring affair. The Dolphins and Bills both averaged over 28 points in Week 1. With playmakers like Tyreek Hill and Stefon Diggs, and two QBs that thrive in up-tempo offenses, the over/under line of 50.5 looks reachable.

Defensively, both teams struggled to contain chunk plays. Miami gave up 390 yards to the Chargers, while Buffalo allowed 7.1 yards per pass against the Jets.

When looking at football betting lines NFL bettors circle for shootout potential, this game tops the list. Don’t be surprised if this total climbs to 52 or more before kickoff.

Our Parlay Picks

Safer Parlay: Ravens -4, Lions +2.5, 49ers -6.5

The Ravens looked dominant in Week 1, and they're facing a young Texans team still searching for rhythm. Detroit, as noted, matches up well with the Rams and has the stats to cover the spread. The 49ers looked like contenders last week, and they're up against a struggling Cardinals squad.

This three-leg parlay offers a mix of favorites and a live underdog. With odds around +500, it’s a balanced wager for football betting fans who like value without huge risk.

Riskier Parlay: Jaguars Moneyline, Dolphins Moneyline, Bears +6.5

This parlay is for bettors who want big upside. The Jaguars are a solid underdog play, while Miami can absolutely outscore Buffalo if their defense holds. The Bears, getting nearly a touchdown, face a shaky Saints offense that just lost their top receiver.

If all three legs hit, the return is around +1100. This is one of the bolder NFL picks Week 2 predictions, but the matchups align nicely for a big reward.

Final Takeaways

NFL picks Week 2 expert consensus shows early value on teams like Detroit, Jacksonville, and Miami. The lines are moving fast, so staying ahead of the public is key. Watch how NFL odds by week shift as injury updates come in and sharp bets land.

Use NFL betting props, totals, and spreads to diversify your ticket. Whether you’re using the top sportsbooks or still figuring out which sports betting app is the best, every pick should be backed by trends and real stats.

NFL betting Week 2 offers plenty of angles—but smart bankroll management and timing your picks are what separate casual bets from profitable ones.

Check out our full betting toolset to start spotting profitable lines.