Best Picks for Week 3 of the 2025-26 NFL Season

Best Moneyline Pick: Lions (+120) vs. Packers

Detroit is once again a popular underdog play. At +120, the Lions carry about a 45 percent implied win probability, but market trends and recent form suggest better value. Last season, Detroit covered 12 of 18 games and outperformed the nfl betting public in prime spots. They return their full offensive line, giving quarterback Jared Goff more protection than most units in the NFC.

Green Bay’s defense is solid against the run, but the Packers rank bottom 10 in explosive pass plays allowed. Detroit’s passing attack can stretch the field, creating mismatches in coverage. Experts note that the Lions have won six of the last ten against Green Bay, including two straight in Lambeau. For Week 3 NFL betting, this moneyline pick blends history, roster depth, and undervalued odds.

Best Spread Pick: Eagles (-6.5) vs. Giants

Point spread betting favors the defending champs. The Eagles are laying -6.5 against the Giants, a number worth grabbing before it climbs to a full touchdown. Philadelphia has covered 14 of their last 16 home openers and continues to dominate against NFC East rivals.

New York enters with offensive line problems, highlighted on the NFL injury report. Protection issues lead to short drives and turnovers, which play right into the hands of a dominant Eagles pass rush. Vegas NFL odds by week often swing based on key injury news, and early bettors know this is a soft line.

The Eagles average over 29 points per game at home across the last two seasons, while the Giants rank near the bottom in scoring defense. Laying less than a touchdown with a proven home powerhouse makes Philadelphia the best spread pick for Week 3 NFL betting.

Best Totals: Ravens at Bills – Over 52.5

If you’re looking at nfl betting props or totals, this game screams offense. Buffalo averaged 30.9 points per game last year, while Baltimore sat close behind at 30.5. Both teams rank top five in red-zone efficiency and feature dual-threat quarterbacks who can break games open.

Defensively, both units showed cracks early this season. Buffalo allowed 27 points in Week 1 and continues to struggle against tight ends, a key issue when facing Mark Andrews. Baltimore’s secondary is banged up, which could allow Josh Allen to push the ball deep.

With NFL odds and predictions pointing toward a shootout, the over 52.5 has strong value. Weather is expected to be mild, removing concerns about wind or rain in Orchard Park. For NFL betting today, this totals play offers explosive upside and a straightforward handicap.

Our Parlay Picks

Safer Parlay: Eagles -6.5, Commanders -3, Lions +3

This combination blends two reliable favorites with a resilient underdog. The Eagles cover machine makes the -6.5 a strong anchor. Washington, favored by a field goal, matches up well against a rebuilding Cardinals roster. Adding Detroit at +3 provides protection on a game likely decided late. Combined, these nfl betting games offer roughly +550 odds, a balanced payout with lower risk.

Riskier Parlay: Lions Moneyline, Ravens Moneyline, Jets +7

Here’s the swing-for-the-fences ticket. Detroit’s moneyline has strong value as mentioned. Baltimore taking down Buffalo on the road would be a statement win, but the roster is built for it. The Jets, meanwhile, are catching a full touchdown against Miami. If their defense limits explosive plays, they can keep it close. This parlay carries about +1200 odds, risky but appealing for NFL betting this week.

Final Takeaways

Week 3 NFL betting gives fans a chance to spot value before lines tighten. From moneyline underdogs to point spread betting on favorites, the edges often come from watching nfl odds and scores move through the week. Factor in the nfl injury report and betting trends, and you can build cards that balance risk and upside.

Remember, NFL Sunday football is a marathon, not a sprint. Stick with strong data, pay attention to nfl betting spreads, and avoid chasing steam. Whether you’re building parlay bets or focusing on single wagers, discipline wins long-term.

Check out our full betting toolset to start spotting profitable lines.