Best Picks for Week 4 of the 2025-26 NFL Season

Best Moneyline Pick: Detroit Lions (+112) at Minnesota Vikings

Detroit has been sharp on both sides of the ball, and that balance makes them our top pick for NFL picks Week 4 straight up. The Lions are sitting at +112 on the moneyline, offering strong value in what looks like a toss-up game on paper.

Detroit’s offensive line continues to dominate. They've allowed just 3 sacks over three weeks and rank top five in rushing efficiency. Meanwhile, the Vikings' defense has struggled, allowing 27.3 points per game and ranking bottom 10 in opponent red-zone scoring.

Recent trends support the pick. The Lions are 5–1 straight up in their last six games as road underdogs. For those wondering where to bet on football games, this matchup is a great way to test out moneyline value. See more in our full breakdown of the Best Moneyline Pick: Lions vs. Vikings (+112).

Best Spread Pick: Philadelphia Eagles (-6.5) vs. New York Giants

When looking at NFL picks Week 4 spread, the Eagles at -6.5 offer one of the most dependable options. Philadelphia is 9–2 against the spread (ATS) in its last 11 divisional games. They’ve also won their last five home games by an average of 9.4 points.

The Giants, on the other hand, are having trouble on offense. Their offensive line ranks 28th in pass protection, and Daniel Jones has been sacked 13 times already this season.

Add to that the Eagles’ defensive front, which ranks second in pressure rate, and it’s easy to see how this line could widen closer to game day. If you’re tracking NFL betting spreads, this is a line to grab early.

Best Totals: Buffalo Bills at Kansas City Chiefs – Over 52.5

This matchup screams points and is our top pick for NFL picks Week 4 predictions in the totals market. Both the Bills and Chiefs rank in the top five in offensive yards per play. Josh Allen and Patrick Mahomes are averaging over 260 passing yards per game.

Last year, these teams combined for 65 points in their regular season meeting. Weather looks clear in Kansas City, with minimal wind and no rain expected—perfect conditions for a shootout.

Kansas City’s secondary has been giving up chunk plays, and Buffalo leads the league in offensive touchdowns through three weeks. If you’re scanning football betting lines NFL, this is a great over bet.

Our Parlay Picks

Safer Parlay: Eagles -6.5, Jaguars -3.5, Lions +2.5

This three-leg parlay blends dependable favorites with a solid underdog cover. The Eagles' spread has already been covered above. Jacksonville faces a struggling Colts team with a rookie QB prone to turnovers. The Lions at +2.5 give us coverage in a close matchup with strong moneyline upside.

Together, this parlay pays around +450 and is a solid play for those easing into betting NFL football.

Riskier Parlay: Lions Moneyline, Bills Moneyline, Panthers +6

Going bold? This mix could produce a major payout. The Lions on the moneyline offer positive odds. The Bills upset potential at Arrowhead brings serious juice. The Panthers are trending up and could catch the Saints off guard, especially with Derek Carr questionable.

This three-leg parlay could net around +1100, depending on your book. While it’s not for the faint of heart, it's worth a look for those seeking NFL betting props and higher-risk angles.

Final Takeaways

Week 4 of the 2025 NFL season is rich with NFL betting today opportunities. From strong value in moneyline plays to favorable point spreads and high-scoring totals, there’s something for every betting style.

Keep an eye on NFL odds by week, especially lines that cross key numbers like 3 or 7. As always, stay disciplined, manage your bankroll, and be aware of line movement. For fans looking for which sports betting app is the best, start with platforms offering live line tracking, same-game parlays, and early cashout options.

Check out our full betting toolset to start spotting profitable lines.