Cowboys vs Eagles: Thursday Night Football Bets to Make on Week 1

Best Moneyline Pick: Eagles (–310) vs Cowboys

Betting the moneyline in a division rivalry like this takes guts—but not a spreadsheet. The Eagles at –310 might not scream value, but hear us out: they beat Dallas by a combined 62 points last season. And they’re coming off a Super Bowl win where they outclassed the Chiefs 40–22.

Philly returns its full offensive line and has the league’s best pass-rush unit, which is bad news for Dallas’ shaky new-look offense. The Cowboys enter Week 1 with a rookie head coach, a reshuffled offensive line, and injuries stacking up in the secondary.

Philly’s dominance at home is no fluke either—they’ve won 14 of their last 15 in Lincoln Financial. Betting the NFL odds in Vegas, it’s clear: this is Philly’s game to lose. The Eagles are a safe moneyline anchor, especially for those stacking parlay bets.

Best Spread Pick: Eagles –7 vs Cowboys

We’re rolling with the Eagles at –7 against the spread. It opened at –6 and moved to –7 for a reason. Bettors know the Eagles aren’t just better—they’re point spread betting gold at home.

Philly has covered the spread in 14 of its last 15 home openers. Dallas, meanwhile, tends to come out the gate slow. Losing veteran Zack Martin on the offensive line hurts, especially when facing Philly’s relentless D-line.

Dak Prescott will be pressured all night, and with limited weapons and a questionable run game, expect stalled drives. Add in a loud Philly crowd and a polished Hurts-led offense? This –7 feels more like a –10. If you're tracking NFL odds by week, this one’s already on the move.

Still wondering Thursday Night Football who won last time? It was Philly. Big.

Best Totals Pick: Over 46.5 – Cowboys vs Eagles

Let’s talk over/under. Oddsmakers set the total at 46.5 for this one, and we're taking the over.

Why? Because both teams can score in bunches—even if Dallas is banged up. The Eagles averaged 31 points per game last season and have only gotten more explosive. Dallas, despite issues, still has Dak and CeeDee Lamb, and garbage-time points count too.

Early-season defenses are usually sloppier. Tackling is rusty. Timing’s still off. And when you’ve got two high-powered offenses with something to prove, you bet on fireworks.

Expect turnovers, quick scores, and plenty of red zone trips. If you're checking NFL betting odds or building out nfl odds and predictions, this total screams shootout.

Our Parlay Picks for the Cowboys vs Eagles Game

Safer Parlay: Eagles –7, Commanders –6.5, Bills –3

This 3-leg parlay keeps it tight with favorites who match up well.

• Eagles –7: See above—dominance in the trenches and home field edge.
  
  
• Commanders –6.5 vs Giants: The Giants are still figuring out their O-line.
  
  
• Bills –3 vs Ravens: At home with more offensive balance.
  
  

At around +600 odds, this parlay has the stats and matchup support to feel sharp. A perfect setup for Thursday Night Football Amazon Prime viewers looking to kick off the season strong.

Riskier Parlay: Cowboys +7, Ravens Moneyline, Lions Moneyline

Want to bet against the grain? This parlay goes bold:

• Cowboys +7: Fade the public steam—Dallas is the most bet underdog at BetMGM.
  
  
• Ravens Moneyline: Upset alert in Buffalo. Lamar’s healthy, and the Bills' secondary is shaky.
  
  
• Lions Moneyline at Packers: Detroit covered 12 of 18 games last season.
  
  

At +1200 odds, this combo delivers if the Cowboys keep it close and the road dogs show up. High risk, high flex potential. This is the kind of ticket you show off in the group chat before Thursday Night Football streaming kicks off.

Final Takeaways

Week 1 is all about overreactions—and opportunity. The Cowboys vs Eagles matchup is full of sharp betting angles. Philly looks like a juggernaut, but public money’s been backing Dallas like they know something. That sets up value on both sides, depending how you like to play it.

Keep an eye on line movement, watch for injury reports, and remember: bankroll discipline beats hot takes.

And if you're still asking, Thursday Night Football is on what channel? It’s streaming on Amazon Prime, kickoff time at 8:20 PM ET.

Check out our full betting toolset to start spotting profitable lines.