NFL Injury Report for Week 2

Brock Purdy’s Toe Injury Clouds 49ers vs Saints

San Francisco opened the season hot, but Purdy came out banged up. He hurt his toe and shoulder, with the toe raising real questions about his Week 2 start. If he sits, Mac Jones could step in. That shift alone would shake nfl betting spreads.

For example:

• With Purdy, Vegas books listed San Francisco at -4.5.
  
  
• Without him, oddsmakers hinted it could drop near a pick’em.
  
  

That swing shows why tracking the NFL injury report is vital. Bettors hunting NFL betting today need to watch daily practice updates. The NFL betting public is already shifting money toward the Saints in anticipation of a late scratch.

Read more: Looking for the ultimate guide to NFL betting this season? We've got you covered right here!

George Kittle Out Several Weeks

The 49ers also lost George Kittle to a hamstring issue. He’s expected to miss 3–5 weeks. His absence removes a red-zone weapon and weakens San Francisco’s passing game.

For nfl betting player props, this creates an opportunity. Wideouts like Brandon Aiyuk and Kendrick Bourne become bigger targets. Bettors can look at touchdown props or receiving yard overs.

Example: If Aiyuk’s line is set at 62.5 receiving yards, the over under feels playable given Kittle’s absence. That’s the type of angle that makes nfl betting games more predictable when you follow injuries closely.

How Injuries Shift NFL Odds in Vegas

A quarterback injury is the most impactful for nfl odds by week. Running back and wide receiver absences matter, but losing a QB changes everything. Sportsbooks often move the line 3–6 points.

Let’s take another case: If a star running back is ruled out, the spread may move a single point. But if a QB is scratched, the entire nfl odds and predictions market shifts. Sharps hit the opening lines, while the nfl betting public chases after the move.

This is why point spread betting is tied so closely to the injury report. Early bettors with inside info on injuries often beat Vegas before lines adjust.

Other Notable Injuries Around the League

Week 2 also brings concerns for:

• Wide receivers nursing hamstring tweaks in Kansas City.
  
  
• A starting cornerback in Buffalo questionable with a groin injury.
  
  
• A top running back in Miami managing an ankle sprain.
  
  

These aren’t headline injuries like Purdy or Kittle, but they still matter. For example, a missing cornerback can push an over under total higher, because opposing receivers will face softer coverage. Bettors tracking NFL betting props can target wideout yardage overs or anytime touchdown markets.

Week 2 NFL Betting and Player Props

NFL Sunday football isn’t just about sides and totals. Props are where injuries really create edges.

Here are a few spots:

• Backup tight ends often see inflated player prop lines when a starter is out. The market overreacts, and unders become valuable.
  
  
• Replacement running backs may face stacked boxes, lowering their rushing efficiency. Betting unders on rushing props is often smarter than chasing overs.
  
  
• Wide receivers stepping into larger roles are the best overs to target, especially in parlay bets.
  
  

For Week 2 nfl betting props, bettors should watch injury reports up until game day. Even late news, like a wideout ruled out in warmups, can shift markets fast.

How the NFL Injury Report Impacts Parlays

Parlay bets live and die by surprises. A single nfl injury can ruin a ticket or create hidden value. The trick is to build parlays after you know who’s active.

Example:
Imagine building a three-leg parlay around 49ers vs Saints. If you lock in early and Purdy sits, you’re holding a dead ticket. But if you wait until inactives are official, you can still grab value on Saints moneyline, combine it with an over in another game, and a touchdown prop elsewhere.

This is why Shurzy always says: parlays > pivot tables, but only if you’re betting with info, not guesses.

NFL Betting Spreads and Public Money

The nfl betting public loves favorites, but injuries tilt that balance. If a star is hurt, bettors often panic and hammer the other side. This creates value on the original favorite if the injury is minor.

For Week 2 nfl betting spreads, track public money percentages. If 70% of tickets are on the Saints due to Purdy’s toe, but Vegas hasn’t moved the line much, it’s a clue. The house may believe Purdy plays, meaning there’s value on San Francisco.

Over Under Totals and Injuries

Injuries to skill players usually affect totals more than spreads. If key offensive stars are out, books shade totals downward. But defense matters too.

For example: If Miami’s starting cornerback sits, totals rise because opposing receivers are expected to torch backups. Bettors who understand both sides of the NFL injury report can beat the market on over under plays.

Betting Example: Week 2 49ers vs Saints

Let’s tie it together with one specific case.

• If Purdy plays at 80%, expect conservative play-calling. That leans under 43.5 total points.
  
  
• If Purdy sits, Mac Jones takes over. Expect more turnovers and short fields, which could push the over.
  
  
• Kittle being out makes touchdown props for Aiyuk or Bourne more attractive.
  
  

This is why nfl betting odds and scores are tied so closely to health. One injury changes the script, and smart bettors adjust faster than the books.

Final Thoughts on NFL Betting This Week

The Week 2 NFL injury report is already shaping the board. From Purdy’s toe to Kittle’s hamstring, bettors who track health news have the edge. Remember, nfl betting odds move quickly once injuries are confirmed. Don’t bet blind.

Use injuries to shape your NFL betting props, parlays, and spreads. Watch nfl odds in Vegas shift live, and be ready to pounce before the market settles.

Check out our full betting toolset to start spotting profitable lines.