NFL Moneyline Matchups for Week 2 (and Predictions)

What is the NFL Moneyline (and Why It’s Perfect for Week 2)

Betting the NFL moneyline means you’re just picking winners. That’s it. No point spread. No crazy math. If your team wins, you cash. Simple. In Week 2, that clarity is golden. The first week always brings surprises—injuries, busted preseason hype, and weird weather games. But now? We’ve got just enough data to start making sharper calls without diving into spreadsheets.

Let’s say the Lions are +140 against the Chiefs. That means a $100 bet gets you $140 if Detroit pulls it off. Flip it—if KC is –160, you’d need to bet $160 to win $100. Welcome to point spread betting's cooler, simpler cousin.

Read more: Looking for the ultimate guide to NFL betting this season? We've got you covered right here!

Week 2 NFL Betting: Top Moneyline Picks

Here’s what we’re looking at for NFL odds by week, especially Week 2. These lines are moving fast, so we’re locking in a few that stand out. These aren’t “safe” picks—they’re smarter-than-your-buddy picks.

Packers at Falcons

Current line: Packers –115
This one’s tight. Both teams come in 1–0, and the NFL betting spreads are close to a pick'em. The Falcons looked solid, but Jordan Love showed poise on the road. We’re leaning Green Bay on the moneyline—barely.

Prediction: Packers win 23–20
Pick: Packers ML

Bears at Buccaneers

Current line: Buccaneers –130
This line feels like a trap, which means it’s probably not. Baker looked shockingly functional in Week 1, and the Bears still can’t stop a nosebleed. Don’t overthink it.

Prediction: Buccaneers win 20–17
Pick: Buccaneers ML

Long-tail keyword drop: nfl odds and scores

When comparing NFL odds and scores, the Bucs' Week 1 win might not pop off the stat sheet—but they kept things clean. That’s more than we can say for Chicago.

Raiders at Bills

Current line: Bills –400
There’s not much value here unless you’re into futures or building parlays. But Buffalo at home, coming off a loss, is a bounce-back special. The Raiders squeaked out a win, but don’t bet on lightning striking twice.

Prediction: Bills win 27–16
Pick: Bills ML

Chargers at Titans

Current line: Chargers –130
The Chargers can’t stop anyone, but they also drop 30 like it’s nothing. Tennessee’s defense is legit, but their offense... isn’t. If you’re chasing a road dog, this ain’t it.

Prediction: Chargers win 26–21
Pick: Chargers ML

Reading NFL Odds in Vegas: What the Books Are Saying

The NFL odds in Vegas don’t lie—they just hint. Week 2 moneylines are sharp because now sportsbooks have seen these teams live. You’ll spot trap games, inflated lines based on public overreaction, and big-name teams that are actually mid.

Example: Cowboys opened as –160 favorites against the Jets, but without Rodgers, the line jumped to –240. Vegas adjusted fast. If you got in early, you're flexing already.

Chiefs at Jaguars

Current line: Chiefs –145
The Jags are hot, but Mahomes is coming in off a loss and (maybe) getting Kelce back. This feels like a shootout, but KC’s weapons edge it.

Prediction: Chiefs win 30–28
Pick: Chiefs ML

Colts at Texans

Current line: Texans –110
Welcome to the gross game of the week. Rookie QBs, bad lines, and chaos. We’ll lean Stroud at home, but this is a coin flip. Literally.

Prediction: Texans win 19–17
Pick: Texans ML (barely)

Long-tail keyword drop: nfl spread for week 2

Oddsmakers are treating this like a dead-even matchup. When you check the NFL spread for Week 2, it’s sitting close to zero. Go with the home team if you must bet it.

Seahawks at Lions

Current line: Lions –135
Seattle looked out of sync in Week 1, while Detroit pulled off a stunner. Now they’re at home, with a rabid crowd and confidence. Good enough for us.

Prediction: Lions win 28–23
Pick: Lions ML

Point Spread vs. Moneyline: When to Skip the Spread

We get it—point spread betting gives you better odds. But sometimes it’s just not worth sweating the hook. In close games, the NFL moneyline lets you back the better team without worrying if they win by 2 or 6.

Jets at Cowboys

Current line: Cowboys –240
No Rodgers. No chance. The Jets’ D is tough, but unless Zach Wilson turned into 2015 Brady overnight, this one’s toast.

Prediction: Cowboys win 24–10
Pick: Cowboys ML (add to parlay)

Dolphins at Patriots

Current line: Dolphins –125
Miami’s speed vs. Belichick’s brain. This one’s going to be closer than people think. But in tight games, we roll with the team that can score from anywhere.

Prediction: Dolphins win 27–24
Pick: Dolphins ML

Long-tail keyword drop: nfl betting odds

If you’re tracking NFL betting odds, Miami’s line has already moved since Sunday night. Might keep creeping. Hit it now.

Final Moneyline Picks (Quick-Fire Style)

Here’s your cheat sheet. Straight up. No fluff.

• Packers ML
  
  
• Buccaneers ML
  
  
• Bills ML
  
  
• Chargers ML
  
  
• Chiefs ML
  
  
• Texans ML
  
  
• Lions ML
  
  
• Cowboys ML
  
  
• Dolphins ML
  
  

And if you’re feeling spicy? Parlay: Bills, Cowboys, Dolphins = profit potential.

Why the NFL Moneyline Rules for Casual Bettors

Look—we’re not here to break down DVOA rankings or force you into NFL teams ranked charts. We’re here for fun bets that cash. The NFL moneyline is the cleanest way to do that. It’s fast. It’s simple. And it’s way more fun to just root for a W than sweat some garbage-time field goal that ruins your spread.

If you're tired of chasing NFL betting spreads or second-guessing totals, go moneyline this week. And don’t worry—we’re watching the over under too. It’s baked into our callouts without drowning you in stats.

Check out our full betting toolset to start spotting profitable lines.

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