Our 5 Betting Tips for NFL Sunday Football Week 1

Best Moneyline Pick: Detroit Lions (+108) at Green Bay Packers

Detroit as a Week 1 underdog? Yep, and we’re riding with the Lions moneyline here. Green Bay opened as slight favorites (-1.5), but line movement is already showing respect for Detroit, tightening to just -1. The Lions sit at +108, giving nearly 48% win probability—and with their 15-2 finish last season (including a clean sweep of the NFC North), they’ve got every reason to bark.

The Lions return all five O-line starters, which is huge against Green Bay’s front seven. Jared Goff has quietly turned into a rock-solid playmaker, especially in close games. Green Bay's defense allowed 4.0 yards per rush last season—decent, but Detroit matched them blow-for-blow and brings more firepower.

This isn’t just a value play—it’s a bet backed by trends, talent, and a team hungry to own this division again. NFL betting odds love a sharp underdog early, and this one’s barking.

Best Spread Pick: Philadelphia Eagles (-7) vs. Dallas Cowboys

Let’s not overthink this. Philly at home in a Week 1 spot against a banged-up Cowboys squad is everything you want in a spread pick. The Eagles opened at -6, and sharp action pushed that to -7—and it could hit -8 by kickoff.

Philly has covered in 14 of their last 15 home openers. Meanwhile, Dallas is dealing with major O-line changes after Zack Martin’s retirement and uncertainty around Dak Prescott’s health. That’s not great when you're facing one of the nastiest front sevens in football.

The NFL betting public is already leaning Eagles-heavy, and so are we. Point spread betting only works when you trust the bully—and Philly is still the biggest, baddest team in the NFC East. Throw in some extra juice from Sunday Night Football hype and you’ve got a pick you can flex.

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Best Totals Pick: Baltimore Ravens at Buffalo Bills – Over 51.5

This is the “just bet the over” game of the week. Baltimore and Buffalo both averaged over 30 points per game last season, and neither defense looks elite against the pass heading into Week 1. The over/under line opened at 51.5, and while that’s high, it’s justified.

Both teams play fast, love to go deep, and have QBs who thrive in big-game moments. Weather in Buffalo in early September? Mild. Translation: Lamar and Josh Allen are about to air it out.

NFL odds and predictions point toward a shootout. Whether you’re watching for the score or riding player props (hello, WR anytime TD bets), this one screams points. The over is the move.

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Our Parlay Picks for the Commanders vs. Giants Game

Safer Parlay: Eagles -7, Commanders -7, Lions +1.5

This one’s got legs. Philly looks dominant at home, the Commanders have a clear edge over a Giants team still rebuilding its O-line, and the Lions getting a small cushion (+1.5) against Green Bay is value.

At +600 odds, it’s the kind of Sunday football pick that feels chalky—but cashes. You’re not reinventing the wheel here, just riding with smart, high-floor teams. If you’re new to parlay bets, this is your perfect intro.

Riskier Parlay: Lions Moneyline, Ravens Moneyline, Giants Moneyline

Want chaos? Cool. This parlay pays around +1200 and banks on volatility in the trenches. The Lions have a legit shot on the road, the Ravens can edge out the Bills in a tight one, and the Giants? They're a wild card, but divisional games in Week 1 get weird.

We’re not saying it’s likely. We’re saying it’s spicy—and worth a sprinkle if you’re chasing a story to brag about in your fantasy group chat.

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Final Whistle

NFL Sunday Football is more than just a vibe—it’s a betting playground. With lines moving fast, injuries brewing, and the public overreacting to preseason buzz, Week 1 is where sharp bettors eat. Whether you’re hitting parlays, chasing overs, or just want bragging rights in your group chat, the board’s got something for everyone.

Remember: smart bets beat lucky ones, and bankroll discipline wins long term. This is the start of a long season, and Sunday night football is just the beginning.

Check out our full betting toolset to start spotting profitable lines.