Our 5 Betting Tips for NFL Sunday Football Week 2

Best Moneyline Pick: Detroit Lions (+108) vs. Green Bay Packers

Detroit comes into NFL Sunday Football with momentum after a strong Week 1. Sportsbooks have Green Bay favored by a single point, but the Lions sit at a tempting +108 on the moneyline. That gives bettors nearly even odds while still offering value.

Why lean Detroit? Last season, the Lions went 15-2 overall and dominated the NFC North. Their offensive line returns intact, a critical strength when facing Green Bay’s front seven. On defense, Detroit allowed just 4.1 yards per carry, nearly identical to the Packers’ numbers.

The Lions have won six of their last ten against Green Bay. With a solid rushing attack and proven ability to handle division rivals, this is one of the best NFL Sunday Football Week 2 bets on the board. For more insights, see our Best Moneyline Pick: Team vs. Team (With +/-).

Read more: Looking for the ultimate guide to NFL betting this season? We've got you covered right here!

Best Spread Pick: Philadelphia Eagles (-7) vs. Dallas Cowboys

The defending champions enter Week 2 as a touchdown favorite at home. NFL odds in Vegas opened at -6 but quickly moved to -7, showing confidence in the Eagles. Despite the line shift, there’s still value here.

Philly has covered the spread in 14 of its last 15 home openers, a stat that shouldn’t be ignored. The Cowboys, meanwhile, face uncertainty after key offensive line retirements and lingering injuries at quarterback. That makes Dallas vulnerable early in the season.

The Eagles average more than eight points per game over opponents in their last ten home contests. Given that dominance, laying seven points feels like one of the safer NFL Sunday Football Week 2 bets. When you’re eyeing nfl betting spreads, this is a clear standout.

Best Totals: Baltimore Ravens at Buffalo Bills – Over 51.5

When it comes to nfl odds by week, this matchup stands out. Oddsmakers set the total at 51.5, a high number that reflects the offensive firepower of both teams. But there’s reason to believe the over is still in play.

Last season, Buffalo averaged 30.9 points per game, tops in the AFC. Baltimore wasn’t far behind, putting up 30.5 per contest. Both teams excel at pushing tempo and stretching defenses vertically. On the flip side, neither secondary ranks among the elite.

With mild September weather in Orchard Park, passing conditions will be ideal. Expect explosive plays and plenty of scoring. If you’re looking at nfl odds and predictions, this over under pick is a strong option for NFL Sunday Football Week 2.

Our Parlay Picks

Safer Parlay: Eagles -7, Commanders -7, Lions +1.5

This 3-leg parlay combines two strong favorites with a road underdog offering value. The Eagles -7 is supported by dominant home trends. Washington at -7 faces a Giants team still working out O-Line issues, giving the Commanders the edge. Adding Lions +1.5 balances the ticket with a team that has covered in 12 of their last 18 games. This mix of nfl betting odds leans safer while still providing a payout around +600.

Riskier Parlay: Lions Moneyline, Ravens Moneyline, Giants Moneyline

For those who want higher upside, this combo delivers. Detroit has the tools to upset Green Bay outright. The Ravens in a shootout with Buffalo always carry value. The Giants add volatility but also payout potential. At about +1200 odds, this parlay is one of the boldest NFL Sunday Football Week 2 bets you can try. It’s the kind of card that turns nfl betting props into bragging rights.

Final Takeaways

NFL Sunday Football is the perfect stage for smart betting in Week 2. From moneyline value to nfl betting spreads and over under totals, opportunities are everywhere. Remember that nfl odds in Vegas shift quickly, and tracking nfl odds and scores helps spot changes. Keep an eye on Sunday Night Football Bets too—knowing Sunday night football is on what channel tonight, who the Sunday night football commentators are, and even details like the Sunday night football song or Sunday night football theme can add to the experience.

NFL Sunday day football offers plenty of action, but smart bankroll management is still key. Bet with confidence, enjoy the ride, and stay disciplined.

Check out our full betting toolset to start spotting profitable lines.