NFL Moneyline Matchups for Week 4 (and Predictions)

Why Moneyline Betting Matters in NFL Betting

Moneyline bets are simple. Instead of worrying about nfl betting spreads, you just back the team you think will win. A favorite might be listed at -180, meaning you risk $180 to win $100. An underdog might be +160, meaning a $100 bet wins $160.

This makes moneyline plays ideal for new bettors or for those building parlay bets. They also highlight where oddsmakers and the nfl betting public disagree. For Week 4 NFL betting this week, that means plenty of chances to profit on overlooked underdogs.

Read more: How to Spot Trends in Online Betting in the NFL

The Role of the NFL Injury Report in Moneyline Matchups

The NFL injury report is critical for moneyline betting. If a starting quarterback is out, the line shifts dramatically. Unlike point spread betting, where backups can still cover, moneyline wagers depend fully on winning outright.

For Week 4, several playoff contenders are dealing with injuries at key positions. Smart bettors will check daily updates and move quickly when NFL odds by week adjust to the news. That’s how you beat the books before the public catches up.

Heavy Favorites and NFL Odds in Vegas

Some Week 4 matchups feature clear favorites. These are the games where NFL odds in Vegas put moneylines at -300 or higher. While the payout is smaller, these plays can still be useful in building parlays.

Take a dominant team like San Francisco at home against a weaker opponent. At -325, the return is limited. But paired with another strong favorite, the parlay odds climb quickly. That’s why moneyline favorites remain a key part of nfl betting games each week.

Live Underdogs and NFL Odds by Week

The best value often comes from live underdogs. These are teams priced around +150 to +250 that have a real chance to win. In Week 4, divisional games often create this opportunity. Rivalries tighten results, making spreads less reliable.

For example, if the Steelers are +180 against the Ravens, but recent scores show they’ve split the last six matchups, the value sits with Pittsburgh. Tracking NFL odds by week helps spot when oddsmakers undervalue teams in these spots.

Over Under Totals and Moneyline Bets

Totals can guide moneyline decisions. If a game has a low over under around 39.5, oddsmakers expect a close, defensive battle. In those cases, underdogs gain more value, since one or two plays can swing the outcome.

By contrast, in a game with a high total near 54.5, favorites often hold serve because scoring volatility evens out. Combining moneyline picks with over under wagers can make parlay bets more appealing for NFL betting today.

Public Trends and NFL Betting Moneylines

The NFL betting public loves big names and popular teams. That often inflates moneyline prices, creating value on the other side. If 70% of tickets are on Dallas at -160, oddsmakers might shade the line, leaving value on the opponent at +140.

This is why tracking NFL odds and scores from past games is so important. History shows where public bias leads to inflated prices, and Week 4 nfl betting props and moneylines are no different.

Example of a Week 4 NFL Moneyline Prediction

Here’s a simple case. Suppose the Lions are +120 underdogs at Green Bay. The NFL betting spreads show Packers -2.5, but Detroit’s offense matches up well against Green Bay’s secondary.

If the Lions win outright 27-24, a $100 moneyline bet at +120 returns $220. This example shows how moneyline wagers often pay more than spread bets when underdogs come through.

Blending NFL odds and predictions with matchup analysis helps uncover these profitable angles.

Building Parlays with NFL Moneyline Bets

Moneyline parlays are one of the most popular strategies in nfl betting this week. By linking two or three favorites, bettors can boost payouts while lowering risk compared to spreads.

For example, combining 49ers -300 with Bills -200 produces a parlay around +120. Add in a live underdog like Lions +120, and suddenly the ticket pays +400 or more. This is how NFL betting props and moneyline wagers combine for bigger scores.

Comparing NFL Betting Odds Across Books

Shopping lines is essential. Different sportsbooks post different nfl betting odds on moneylines. One book might have a team at +135 while another sits at +150. That difference means extra profit on the same pick.

Nfl odds in Vegas often serve as the market baseline, but online books compete by shading lines. Bettors who compare multiple sites get the best price, whether betting favorites or underdogs. It’s a simple but vital step for nfl betting today.

Final Thoughts on NFL Moneyline Matchups for Week 4

NFL moneyline betting is about more than just picking favorites. Week 4 features heavy chalk, live underdogs, and plenty of opportunities shaped by the NFL injury report. Watching how the nfl betting public pushes odds, comparing nfl odds by week, and pairing plays into parlays all create value.

Moneyline wagers remain a foundation of nfl betting games. Paired with spreads, totals, and player props, they give bettors the flexibility to build winning strategies for NFL Sunday football.

Check out our full betting toolset to start spotting profitable lines.